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Sc/f-hmns

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

4

Cellular senescence

downin human cells1

1 study

  1. Sc/f-hmns decrease cellular senescence in human cells.

    “significantly reducing levels of reactive oxygen species (ROS) and DNA damage, and attenuating senescence.”

    Cellsin UVA-irradiated human skin fibroblastsskin

    Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair

    Materials today. Bio12 Oct 2025

More on Cellular senescence

Oxidative stress and ROS signalling

downin mice1

1 study

  1. Sc/f-hmns decrease oxidative stress and ROS signalling in mice.

    “SC/F-HMNs decreased oxidative stress, DNA damage, and restored barrier function”

    Animalsin UVA-irradiated miceskin

    Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair

    Materials today. Bio12 Oct 2025

More on Oxidative stress and ROS signalling

Skin elasticity

upin mice1

1 study

  1. Sc/f-hmns improve skin elasticity in mice.

    “SC/F-HMNs treatment exhibited improvement in skin wrinkles and elasticity.”

    Animalsin UVA-irradiated miceskin

    Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair

    Materials today. Bio12 Oct 2025

Skin wrinkles

downin mice1

1 study

  1. Sc/f-hmns decrease skin wrinkles in mice.

    “SC/F-HMNs treatment exhibited improvement in skin wrinkles and elasticity.”

    Animalsin UVA-irradiated miceskin

    Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair

    Materials today. Bio12 Oct 2025

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