AgingResearch.NewsJoin free

S107

Intervention

2 papers2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Agence Nationale de la Recherche and others
  • Model organisms1
  • Cells1

Outcomes

2

Physical function

upin cells1

1 study

  1. S107 improves physical function in cells (1.65 ± 0.06 μm vs. 2.26 ± 0.08 μm).

    “Stabilizing RyR2 pharmacologically by S107 prevented most of these pathological features, including the rescue of the contraction amplitude (1.65 ± 0.06 μm for DMD vs. 2.26 ± 0.08 μm for DMD + S107, P < 0.01).”

    Cellsin DMD hiPSC-derived cardiomyocytes

    Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy

    Journal of cachexia, sarcopenia and muscle14 Jan 2024

Muscle function

upin worms1

1 study

  1. S107 improves muscle function in worms.

    “Preventing FKB-2 depletion from the UNC-68 macromolecular complex using the Rycal drug S107 improved muscle Ca2+ transients and function.”

    Model organismsaging

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    eLife4 May 2022

Latest

Related