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S-allylcysteine

Intervention

2 papers study it6 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Ministry of Science and Technology, Taiwan and 5 more
  • 2 of 6 findings with company ties
  • Animals1
  • Model organisms1

Outcomes

6

Mitochondrial fission and fusion

upin worms1

1 study

  1. S-allylcysteine improves mitochondrial fission and fusion in worms.

    “SAC treated groups maintain the linear morphology of mitochondria”

    Model organisms5 or 50 μM

    S-Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

    Molecular nutrition & food research

More on Mitochondrial fission and fusion

Cellular senescence

downin mice1

1 study

  1. S-allylcysteine decreases cellular senescence in mice.

    “SAC significantly reduces liver galactosidase β1 (GLB1) and senescence-associated β-galactosidase (SA-βgal)”

    Animalsnaturally ageddietliver0.05% and 0.2%12 weeksmales

    S-Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

    Molecular nutrition & food research

More on Cellular senescence

Oxidative stress and ROS signaling

downin mice1

1 study

  1. S-allylcysteine decreases oxidative stress and ROS signaling in mice.

    “ameliorating oxidative stress, such as malondialdehyde (MDA) in the liver and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in urine”

    Animalsnaturally ageddietliver0.05% and 0.2%12 weeksmales

    S-Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

    Molecular nutrition & food research

More on Oxidative stress and ROS signaling

OPA1

upin mice1

1 study

  1. S-allylcysteine increases OPA1 in mice.

    “SAC could significantly improve the level of hepatic optic atrophy 1 (OPA1) mRNA”

    Animalsnaturally ageddietliver0.05% and 0.2%12 weeksmales

    S-Allylcysteine Ameliorates Aging Features via Regulating Mitochondrial Dynamics in Naturally Aged C57BL/6J Mice

    Molecular nutrition & food research

More on OPA1

Reactive oxygen species

downin worms1

1 study

  1. S-allylcysteine decreases reactive oxygen species in worms.

    “Here we show that SAC and SAMC increase lifespan and stress resistance in Caenorhabditis elegans and reduce accumulation of reactive oxygen species (ROS).”

    Model organisms

    Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

    Scientific reports

More on Reactive oxygen species

Lifespan

upin worms1

1 study

  1. S-allylcysteine extends lifespan in worms.

    “Here we show that SAC and SAMC increase lifespan and stress resistance in Caenorhabditis elegans and reduce accumulation of reactive oxygen species (ROS).”

    Model organisms

    Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

    Scientific reports

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