rhHAPLN1
1 paper studies it3 findings
- 1 lab in 1 country
- Funders: Jeju National University and 3 more
- Animals1
Outcomes
3TGFBR1
upin human cells1
1 study
TGFBR1
upin human cells1
rhHAPLN1 increases TGFBR1 in human cells.
“treating human alveolar epithelial type 2 cells with recombinant human HAPLN1 (rhHAPLN1) increased TGF-β receptor 1 (TGF-β RI) protein levels”
CellsCD44-dependentalveolar epithelial type 2 cells
Molecules and cellsAug 17, 2023
Alveolar space enlargement
downin mice1
1 study
Alveolar space enlargement
downin mice1
rhHAPLN1 decreases alveolar space enlargement in mice.
“Both senile emphysema mouse model induced via intraperitoneal rhHAPLN1 injections and porcine pancreatic elastase (PPE)-induced COPD mouse model generated via rhHAPLN1-containing aerosols inhalations showed a significantly potent efficacy in reducing alveolar spaces enlargement.”
Animalssenile emphysema modelintraperitoneal injectionslung
Molecules and cellsAug 17, 2023
Sirtuin signaling
upin human cells1
1 study
Sirtuin signaling
upin human cells1
rhHAPLN1 activates sirtuin signaling in human cells.
“rhHAPLN1 significantly increased sirtuins levels (i.e., SIRT1/2/6) without TGF-β1”
Cellswithout TGF-β1alveolar epithelial type 2 cells
Molecules and cellsAug 17, 2023
Latest
Molecules and Cells
Recombinant Human HAPLN1 Mitigates Pulmonary Emphysema by Increasing TGF-β Receptor I and Sirtuins Levels in Human Alveolar Epithelial Cells
Experiments in miceLung