Relaxin

1. Relaxin decreases mortality in humans (-37% mortality at 180-days post-treatment).

   “Relaxin-therapy for 2-days reduced mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF”

   Reviewacute decompensated HF2-days

   Relaxin abrogates genomic remodeling of the aged heart

   Vitamins and hormones·18 Feb 2021

1. Relaxin increases GJA1 in rats.

   “increases the expression of voltage-gated Na+ channels (mRNA, Nav1.5 and INa), connexin-43”

   Animalsheart0.4mg/kg/day2-week

   Relaxin abrogates genomic remodeling of the aged heart

   Vitamins and hormones·18 Feb 2021

More on GJA1

1. Relaxin increases SCN5A in rats.

   “increases the expression of voltage-gated Na+ channels (mRNA, Nav1.5 and INa), connexin-43”

   Animalsheart0.4mg/kg/day2-week

   Relaxin abrogates genomic remodeling of the aged heart

   Vitamins and hormones·18 Feb 2021

More on SCN5A

1. Relaxin decreases cellular hypertrophy in rats.

   “reverses myocardial fibrosis and cellular hypertrophy of the aged hearts”

   Animalsheart0.4mg/kg/day2-week

   Relaxin abrogates genomic remodeling of the aged heart

   Vitamins and hormones·18 Feb 2021

1. Relaxin decreases myocardial fibrosis in rats.

   “reverses myocardial fibrosis and cellular hypertrophy of the aged hearts”

   Animalsheart0.4mg/kg/day2-week

   Relaxin abrogates genomic remodeling of the aged heart

   Vitamins and hormones·18 Feb 2021

1. Relaxin inhibits complement system in rats.

   “activation of the complement cascade, whereas relaxin reversed these age-related effects”

   Animalssubcutaneous osmotic mini-pumpsleft ventricle0.4 mg/kg/day2-weeks

   Relaxin reverses inflammatory and immune signals in aged hearts

   PloS one·18 Jan 2018

More on Complement system

1. Relaxin decreases macrophage infiltration in rats.

   “macrophage infiltration and atrial natriuretic peptide levels in female ventricles, and activation of the complement cascade, whereas relaxin reversed these age-related effects”

   Animalssubcutaneous osmotic mini-pumpsventricle0.4 mg/kg/day2-weeksfemales

   Relaxin reverses inflammatory and immune signals in aged hearts

   PloS one·18 Jan 2018

More on Macrophage infiltration

1. Relaxin decreases inflammation in rats.

   “relaxin suppresses transcription of multiple genes and signaling pathways associated with inflammation and HF in both genders”

   Animalssubcutaneous osmotic mini-pumpsleft ventricle0.4 mg/kg/day2-weeks

   Relaxin reverses inflammatory and immune signals in aged hearts

   PloS one·18 Jan 2018

More on Inflammation