Recombinant human HAPLN1
2 papers6 findings
- 1 lab in 1 country
- Funders: National Research Foundation of Korea and 4 more
- Animals1
- Cells1
Outcomes
6endocytic degradation
downin cells1
1 study
endocytic degradation
downin cells1
Recombinant human HAPLN1 prevents endocytic degradation in cells.
“rhHAPLN1 protected transforming growth factor beta receptor 2 on the cell surface from endocytic degradation”
Cellscell surface
Hyaluronan and proteoglycan link protein 1 - A novel signaling molecule for rejuvenating aged skin
Matrix biology : journal of the International Society for Matrix BiologySep 1, 2024
Skin extracellular matrix
upin animals1
1 study
Skin extracellular matrix
upin animals1
Recombinant human HAPLN1 improves skin extracellular matrix.
“levels of various markers, which decrease in aged skin, were significantly restored in vivo and in vitro by the administration of recombinant human HAPLN1 (rhHAPLN1).”
Animalsin aged skin
Hyaluronan and proteoglycan link protein 1 - A novel signaling molecule for rejuvenating aged skin
Matrix biology : journal of the International Society for Matrix BiologySep 1, 2024
Sirtuin signalling
upin human cells1
1 study
Sirtuin signalling
upin human cells1
Recombinant human HAPLN1 increases sirtuin signalling in human cells.
“rhHAPLN1 not only increases the sirtuin 1 (SIRT1) levels”
Cellsin senescent HUVECs
Biomolecules & therapeuticsAug 8, 2023
Angiogenesis
upin human cells1
1 study
Angiogenesis
upin human cells1
Recombinant human HAPLN1 increases angiogenesis in human cells.
“promoting the function and survival of HUVECs and leading to cellular proliferation, migration, and angiogenesis”
Cellsin senescent HUVECs
Biomolecules & therapeuticsAug 8, 2023
Oxidative stress and ROS signalling
downin human cells1
1 study
Oxidative stress and ROS signalling
downin human cells1
Recombinant human HAPLN1 protects against oxidative stress and ROS signalling in human cells.
“rhHAPLN1 protected senescent HUVECs from oxidative stress by reducing cellular reactive oxygen species levels”
Cellsin senescent HUVECs
Biomolecules & therapeuticsAug 8, 2023
Senescence-associated secretory phenotype (SASP)
downin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
downin human cells1
Recombinant human HAPLN1 inhibits senescence-associated secretory phenotype (SASP) in human cells.
“inhibited the production of senescence-associated secretory phenotypes, including IL-1β, CCL2, and IL-6”
Cellsin senescent HUVECs
Biomolecules & therapeuticsAug 8, 2023