RAD140

1. RAD140 decreases AR in mice.

   “AR mRNA was lower with RAD140 treatment in both sexes.”

   Animalswith RAD140 treatmentleft ventricle5 mg/kg/day6-weeks

   Treatment with a selective androgen receptor modulator (RAD140) is linked to better cardiac function, with male-specific effects that are graded by interleukin-6

   GeroScience·17 Feb 2026

More on AR

1. RAD140 improves myocardial strain in mice (-5.8%).

   “RAD140 treated males had better markers of cardiac function, including myocardial strain (-5.8%) and isovolumic relaxation times (-4.7 ms) compared to controls”

   Animalscompared to controlsheart5 mg/kg/day6-weeksmales

   Treatment with a selective androgen receptor modulator (RAD140) is linked to better cardiac function, with male-specific effects that are graded by interleukin-6

   GeroScience·17 Feb 2026

More on Myocardial strain

1. RAD140 increases stroke volume in mice (+ 9.6 μL).

   “stroke volume (+ 9.6 μL) and cardiac output (+ 4.5 mL/min), versus controls.”

   Animalsversus controlsheart5 mg/kg/day6-weeks

   Treatment with a selective androgen receptor modulator (RAD140) is linked to better cardiac function, with male-specific effects that are graded by interleukin-6

   GeroScience·17 Feb 2026

More on Stroke volume

1. RAD140 increases ejection fraction in mice (+ 10.4%).

   “RAD140 treated males and females had higher ejection fraction (+ 10.4%), stroke volume (+ 9.6 μL) and cardiac output (+ 4.5 mL/min), versus controls.”

   Animalsversus controlsheart5 mg/kg/day6-weeks

   Treatment with a selective androgen receptor modulator (RAD140) is linked to better cardiac function, with male-specific effects that are graded by interleukin-6

   GeroScience·17 Feb 2026

More on Ejection fraction