Quercetin + superoxide dismutase

1. Quercetin + superoxide dismutase decreases senescence-associated secretory phenotype (SASP).

   “by effectively attenuating SASP activity in aged DED models, the treatment showed profound disease-modifying efficacy.”

   Animalsdry eye disease models; organism not specifiedpolypeptide-based nanosenolytic eye drop

   Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress

   Bioactive materials·17 Jun 2026

More on Senescence-associated secretory phenotype (SASP)

1. Quercetin + superoxide dismutase decreases dry eye disease manifestations.

   “reversed key DED manifestations.”

   Animalsdry eye disease models; organism not specifiedpolypeptide-based nanosenolytic eye drop

   Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress

   Bioactive materials·17 Jun 2026

1. Quercetin + superoxide dismutase improves lacrimal gland function.

   “restored lacrimal gland function”

   Animalsdry eye disease models; organism not specifiedpolypeptide-based nanosenolytic eye droplacrimal gland

   Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress

   Bioactive materials·17 Jun 2026

1. Quercetin + superoxide dismutase decreases oxidative stress and ROS signalling.

   “leading to suppressed oxidative stress and apoptosis, restored lacrimal gland function, and reversed key DED manifestations.”

   Animalsdry eye disease models; organism not specifiedpolypeptide-based nanosenolytic eye drop

   Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress

   Bioactive materials·17 Jun 2026

More on Oxidative stress and ROS signalling

1. Quercetin + superoxide dismutase increases corneal permeability.

   “This nanoplatform demonstrated superior corneal permeability compared to free SOD”

   Animalscompared with free superoxide dismutase; model organism not specifiedpolypeptide-based nanosenolytic eye dropcornea

   Synergistic nanosenolytic therapy reverses age-related dry eye disease by targeting cellular senescence and oxidative stress

   Bioactive materials·17 Jun 2026