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Queen removal

Exposure

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Model organisms1

Outcomes

4

Lysosome production

upin S. invicta1

1 study

  1. Queen removal increases lysosome production in S. invicta.

    “Metabolite changes relate to unsaturated fatty acid biosynthesis and autophagy, with increased lysosome production in queenless minors”

    Model organismsminor workers after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

MRJP1 expression

upin S. invicta1

1 study

  1. Queen removal increases MRJP1 expression in S. invicta.

    “The queen's absence mildly affects gene expression in major workers, but TO and MRJP1 expression rise in minors.”

    Model organismsminor workers after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

More on MRJP1 expression

TO expression

upin S. invicta1

1 study

  1. Queen removal increases TO expression in S. invicta.

    “The queen's absence mildly affects gene expression in major workers, but TO and MRJP1 expression rise in minors.”

    Model organismsminor workers after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

More on TO expression

Necrophoresis behavior

no changein S. invicta1

1 study

  1. Queen removal has no effect on necrophoresis behavior in S. invicta.

    “Our study compares worker behavior and gene expression post-queen removal, revealing altered dietary preferences, life expectancy, and no change in necrophoresis behavior.”

    Model organismsworker ants after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

Associations

2

Life expectancy

mixedin S. invicta1

1 study

  1. Queen removal is associated with life expectancy in S. invicta.

    “Our study compares worker behavior and gene expression post-queen removal, revealing altered dietary preferences, life expectancy, and no change in necrophoresis behavior.”

    Model organismsworker ants after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

Dietary preferences

mixedin S. invicta1

1 study

  1. Queen removal is associated with dietary preferences in S. invicta.

    “Our study compares worker behavior and gene expression post-queen removal, revealing altered dietary preferences, life expectancy, and no change in necrophoresis behavior.”

    Model organismsworker ants after queen removal

    Multi-Omics Analysis Reveals TO Gene's Association With Food Selection and Lifespan in Minor-Worker Ants Post-Queen Loss

    Ecology and evolution7 Jun 2025

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