Prosaikogenin f

1. Prosaikogenin f decreases daf-2 in worms.

   “whereas that of the daf-2 gene was significantly down-regulated (p < 0.05).”

   Model organisms

   Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A

   Fitoterapia·12 Mar 2026

More on daf-2

1. Prosaikogenin f decreases lipid peroxidation in worms.

   “In addition, they increased the activity of antioxidant enzymes, reduced lipid peroxidation”

   Model organisms

   Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A

   Fitoterapia·12 Mar 2026

More on Lipid peroxidation

1. Prosaikogenin f increases survival time in worms (+35.76%).

   “Under thermal stress stimulation, 120 μM PSF prolonged survival time of nematodes by 35.76% compared to SSA by 33.59%.”

   Model organismsunder thermal stress120 μM

   Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A

   Fitoterapia·12 Mar 2026

1. Prosaikogenin f extends lifespan in worms (+11.41%).

   “Average lifespan of nematodes was extended by 9.32% after treatment with 120 μM SSA, which was further increased to 11.41% while PSF being applied.”

   Model organisms120 μM

   Anti-aging effects of rare prosaikogenin F from microbial biotransformation of saikosaponin A

   Fitoterapia·12 Mar 2026