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PROBIOTIC-4

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Higher Education Discipline Innovation Project and 3 more
  • Animals1

Outcomes

4

DNA damage response

downin mice1

1 study

  1. PROBIOTIC-4 decreases DNA damage response in mice.

    “ProBiotic-4 significantly decreased the levels of γ-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I)”

    Animalsaged SAMP8 miceoralbrain12 weeks

    Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

    Acta pharmaceutica Sinica. B7 Jul 2019

More on DNA damage response

NF-κB signalling

downin mice1

1 study

  1. PROBIOTIC-4 inhibits NF-κB signalling in mice.

    “reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-κB (NF-κB) nuclear translocation in the brain.”

    Animalsaged SAMP8 miceoralbrain12 weeks

    Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

    Acta pharmaceutica Sinica. B7 Jul 2019

More on NF-κB signalling

Blood-brain barrier disruption

downin mice1

1 study

  1. PROBIOTIC-4 decreases blood-brain barrier disruption in mice.

    “ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood-brain barrier”

    Animalsaged SAMP8 miceoralbrain12 weeks

    Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

    Acta pharmaceutica Sinica. B7 Jul 2019

Memory deficits

upin mice1

1 study

  1. PROBIOTIC-4 improves memory deficits in mice.

    “ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice.”

    Animalsaged SAMP8 miceoralbrain12 weeks

    Probiotics modulate the microbiota-gut-brain axis and improve memory deficits in aged SAMP8 mice

    Acta pharmaceutica Sinica. B7 Jul 2019

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