Preventive interventions

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab

Outcomes

Fasting plasma glucose, body mass index, HOMA-IR and total cholesterol

downin humans1

1 study

Preventive interventions decrease fasting plasma glucose, body mass index, HOMA-IR and total cholesterol in humans.
“Reductions were observed for other secondary metabolic outcomes (fasting plasma glucose, body mass index, HOMA-IR and total cholesterol).”
ReviewWithin 5 years of a gestational diabetes mellitus-affected pregnancyfemales
The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus-First update of a living systematic review and meta-analysis
Diabetic medicine : a journal of the British Diabetic Association12 Oct 2026

More on Fasting plasma glucose, body mass index, HOMA-IR and total cholesterol

Frailty

downin humans1

1 study

Preventive interventions decrease frailty in humans.
“Reasonable preventive interventions can restore the elderly to an independent life.”
Reviewin the elderly
Healthy aging, early screening, and interventions for frailty in the elderly
Bioscience trends23 Aug 2023

Associations

Type 2 diabetes

downin humans1

1 study

Preventive interventions lower the risk of type 2 diabetes in humans (15% reduction in risk; 32% reduction in hazard (95% credible interval 0.40–1.07)).
“There was a 15% (95% CrI: 0.69-1.04) and 32% (95% CrI: 0.40-1.07) reduction in risk and hazard ratio for T2DM, respectively”
ReviewWithin 5 years of a gestational diabetes mellitus-affected pregnancyAt least 12 months follow-upfemalesn = 7,379
The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus-First update of a living systematic review and meta-analysis
Diabetic medicine : a journal of the British Diabetic Association12 Oct 2026