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Poneratoxin

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Cells1

Outcomes

3

Autophagy

downin human cells1

1 study

  1. Poneratoxin inhibits autophagy in human cells.

    “It also impaired autophagy by inhibiting ULK1 expression and activity”

    Cellsin vitroSH-SY5Y cells

    Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function

    Scientific reports16 Jul 2025

More on Autophagy

Cellular senescence

upin human cells1

1 study

  1. Poneratoxin induces cellular senescence in human cells.

    “PoTX treatment led to cell cycle arrest, reduced neuronal plasticity, and accelerated cellular senescence.”

    Cellsin vitroSH-SY5Y cells

    Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function

    Scientific reports16 Jul 2025

More on Cellular senescence

Intracellular calcium concentration

upin human cells1

1 study

  1. Poneratoxin induces intracellular calcium concentration in human cells.

    “PoTX significantly induced calcium accumulation in SH-SY5Y cell model.”

    Cellsin vitroSH-SY5Y cells

    Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function

    Scientific reports16 Jul 2025

More on Intracellular calcium concentration

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