Tau aggregates

Biomarker1 paper1 finding

Animals1

Upstream

1

TFEB

downin mice1

1 study

TFEB decreases tau aggregates in mice.
“These stabilized constructs drive increased expression of TFEB target genes and promote clearance of tau aggregates in a model of Alzheimer’s disease.”
Animalsin a model of Alzheimer's disease using stabilized TFEB constructs
Modulating TFEB lysosomal function for aging and Alzheimer's disease · AAIC 2025 abstract · 23 Dec 2025

Latest

17

bioRxivAnimalsPreprint24 Sep

Soluble pathogenic tau transmission to astrocytes drives cellular senescence and neurovascular uncoupling in a model of Alzheimer's tauopathy

Cellular senescence

MicroPublication BiologyModel organisms4 Sep

The effects of obesogenic diet on a Drosophila model of frontotemporal dementia

Frontiers in Molecular NeuroscienceAnimals27 Aug

Investigating the role of EFhd2 protein in modulating tau pathology in a tauopathy mouse model

Biochemical PharmacologyReview22 Aug

Immunopharmacological reprogramming of innate immune memory in Alzheimer's disease: From microglial priming to therapeutic resilience

AAIC 2025 AbstractHumans8 Jan

Evaluating Plasma Ptau‐217 Sensitivity in Detecting Individual Differences in Early‐stage Tau Aggregation in Cognitively Unimpaired Older Adults

AAIC 2025 AbstractHumans7 Jan

VeraBIND Tau test, a novel plasma assay for active tau pathology, identifies individuals with positive tau‐PET signal, regardless of amyloid status

AAIC 2025 AbstractHumans26 Dec

Exposure to TBI increases the susceptibility to tau phosphorylation at pT217

AAIC 2025 AbstractHumans26 Dec

Blood biomarkers of neuronal injury and glial cell dysfunction and 25‐year cognitive decline and incident dementia in the ARIC study

AAIC 2025 AbstractHumans25 Dec

Sex Moderates Relationships Between p ‐Tau217 and Longitudinal Tau‐PET: A Multi‐Cohort Study

AAIC 2025 AbstractReview25 Dec

The evolving roles of imaging and fluid biomarkers for Alzheimer disease over the past quarter century