Polydimethylsiloxane

1. Polydimethylsiloxane increases XRCC5 in human cells.

   “In contrast, 3D substrates exhibited delayed but robust odontogenic responses, coupled with increased epigenetic regulation (HAT-1, HDAC-1) and elevated XRCC5 expression at day 21”

   Cells3D substratesday 21

   Mechanical Memory and NF-κB Signaling in Dental Pulp Stem Cell Odontogenic Differentiation

   Journal of endodontics·Jan 9, 2026

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1. Polydimethylsiloxane increases stem cell differentiation in human cells.

   “The 2kPa substrates significantly enhanced early odontogenic differentiation, evidenced by upregulation of DMP-1 and DSPP, along with higher expression of stemness markers (NANOG, SOX-2).”

   Cells2kPa substrates7 days

   Mechanical Memory and NF-κB Signaling in Dental Pulp Stem Cell Odontogenic Differentiation

   Journal of endodontics·Jan 9, 2026

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