Plerixafor

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs

Animals2
Cells1

Outcomes

Cell viability

no changein human cells1

1 study

Plerixafor has no effect on cell viability in human cells.
“CXCR4 inhibition had no detrimental effects on chondrocyte viability, proliferation, or chondrogenic differentiation potential”
Cellsin isolated human articular chondrocytes exposed to 200 ng/mL CXCL12cartilage
Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases
Arthritis research & therapy2 Dec 2025

Cognitive function

upin mice1

1 study

Plerixafor improves cognitive function in mice.
“significantly improved synaptic plasticity and cognitive performance in aged surgical mice”
Animalsin aged surgical micehippocampal CA1 region
Increased reactive astrocytes in hippocampal CA1 region mediated by decreased CXCR7 is involved in postoperative cognitive dysfunction in aged mice
Cell biology and toxicology3 Oct 2025

Inflammation

downin mice1

1 study

Plerixafor decreases inflammation in mice.
“both astrocyte-specific CXCR7 overexpression in the hippocampal CA1 region and systemic administration of the CXCR7 agonist AMD3100 effectively attenuated astrocyte activation, reduced neuroinflammation”
Animalsin aged surgical micehippocampal CA1 region
Increased reactive astrocytes in hippocampal CA1 region mediated by decreased CXCR7 is involved in postoperative cognitive dysfunction in aged mice
Cell biology and toxicology3 Oct 2025