Plant-based refeeding

1. Plant-based refeeding increases fibroblast growth factor 21 in humans (fivefold (243.2-1176 pg/mL, p = 0.0007)).

   “Changes in BCAAs were inversely associated with a fivefold increase in FGF21 levels (243.2-1176 pg/mL, p = 0.0007)”

   Human trialpost-fastingplant-based refeedingplasma5.3 ± 2.4 days

   The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans

   Aging cell·21 Oct 2025

More on Fibroblast growth factor 21

1. Plant-based refeeding decreases isoleucine in humans (-48%, p < 0.001).

   “yet BCAAs declined sharply (valine -45%, leucine -52%, isoleucine -48%; all p < 0.001)”

   Human trialpost-fastingplant-based refeedingplasma5.3 ± 2.4 days

   The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans

   Aging cell·21 Oct 2025

More on Isoleucine

1. Plant-based refeeding decreases leucine in humans (-52%, p < 0.001).

   “yet BCAAs declined sharply (valine -45%, leucine -52%, isoleucine -48%; all p < 0.001)”

   Human trialpost-fastingplant-based refeedingplasma5.3 ± 2.4 days

   The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans

   Aging cell·21 Oct 2025

More on Leucine

1. Plant-based refeeding decreases valine in humans (-45%, p < 0.001).

   “yet BCAAs declined sharply (valine -45%, leucine -52%, isoleucine -48%; all p < 0.001)”

   Human trialpost-fastingplant-based refeedingplasma5.3 ± 2.4 days

   The Metabolic Transition Between Fasting and Feeding Alters Aging-Associated Metabolites, Lowers BCAAs, and Stimulates FGF21 Production in Humans

   Aging cell·21 Oct 2025

More on Valine