Piperine

1 paper4 findings

PubChem 638024 ChEBI 28821 MeSH C008922

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: Priority Academic Program Development of Jiangsu Higher Education Institutions

Animals1

Outcomes

4

Fatty acid β-oxidation

upin mice1

1 study

Piperine increases fatty acid β-oxidation in mice.
“Additionally, piperine enhanced hepatic mitochondrial β-oxidation in the obese NAFLD model by upregulating carnitine palmitoyltransferase 1A (CPT1A).”
Animalsin obese NAFLD miceliver
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice
Journal of gastroenterology and hepatology9 Dec 2025

More on Fatty acid β-oxidation

Triglyceride

downin mice1

1 study

Piperine decreases triglyceride in mice.
“reduced serum ALT levels and hepatic triglyceride (TG) content”
Animalsin lean and obese NAFLD miceliver
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice
Journal of gastroenterology and hepatology9 Dec 2025

More on Triglyceride

Alanine aminotransferase

downin mice1

1 study

Piperine decreases alanine aminotransferase in mice.
“Piperine treatment significantly reduced serum ALT levels and hepatic triglyceride (TG) content”
Animalsin lean and obese NAFLD miceliver
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice
Journal of gastroenterology and hepatology9 Dec 2025

More on Alanine aminotransferase

Hepatic steatosis

downin mice1

1 study

Piperine decreases hepatic steatosis in mice.
“Piperine treatment significantly reduced serum ALT levels and hepatic triglyceride (TG) content, alleviating hepatic steatosis in both groups.”
Animalsin lean and obese NAFLD miceliver
Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice
Journal of gastroenterology and hepatology9 Dec 2025

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