Phosphoenolpyruvate

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Outcomes

Cognitive function

upin mice1

1 study

Phosphoenolpyruvate improves cognitive function in mice.
“PEP alleviates neuroinflammation and improves cognitive function in an Alzheimer's disease mouse model.”
Animalsin an Alzheimer's disease mouse model
The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging
Nature aging6 Mar 2026

Inflammation

downin mice1

1 study

Phosphoenolpyruvate decreases inflammation in mice.
“PEP alleviates neuroinflammation and improves cognitive function in an Alzheimer's disease mouse model.”
Animalsin an Alzheimer's disease mouse model
The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging
Nature aging6 Mar 2026

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Paper

Aging Cell30 Mar