Phosphatidic acid

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs

Cells2

Outcomes

Cellular senescence

downin mouse cells2

2 studies

Phosphatidic acid decreases cellular senescence in mouse cells.
“In both male and female WT SV cells, PA (16:0-18:1) treatment reduced senescence”
Cellssubcutaneous fat
Sex-Specific Regulation of Adipose Progenitor Cell Senescence by Lipocalin 2 via Phosphatidic Acid–Dependent mTOR Signaling Pathway
ADA Scientific Sessions 2026 abstract5 Jun 2026
Phosphatidic acid decreases cellular senescence in mouse cells.
“PA1 or PA2 significantly reduced β-galactosidase-positive senescent cells as well as downregulated of senescence and senescence-associated secretory phenotype (SASP) marker genes”
Cellsin WT stromal-vascular cellsinguinal white adipose tissue2 days
Lipocalin-2 Regulates the Function of Phosphatidic Acid in Senescence and mTOR Signaling in Adipose Stromal-Vascular Cells
ADA Scientific Sessions 2025 abstract13 Jun 2025