PF-04691502
- 2 independent labs in 2 countries
- Funders: Ministero della Salute and 2 more
- Animals1
- Cells1
Outcomes
5Autophagy
upin mice1
1 study
Autophagy
upin mice1
PF-04691502 activates autophagy in mice.
“Treatment with PF-04691502 increased the LC3-II/LC3-I ratio, upregulated Beclin-1, and elevated LAMP-2 levels, indicative of stimulated autophagosome formation and lysosomal activity.”
Animalsin APP/PS1 miceoral administrationbrain1 mg/kg12 weeks
PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD
Cells
Insoluble amyloid-beta
downin mice1
1 study
Insoluble amyloid-beta
downin mice1
PF-04691502 decreases insoluble amyloid-beta in mice.
“significantly reduced insoluble Aβ accumulation in the brain”
Animalsin APP/PS1 miceoral administrationbrain1 mg/kg12 weeks
PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD
Cells
Cognitive function
upin mice1
1 study
Cognitive function
upin mice1
PF-04691502 improves cognitive function in mice.
“PF-04691502 enhanced cognitive performance in APP/PS1 mice”
Animalsin APP/PS1 miceoral administrationbrain1 mg/kg12 weeks
PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD
Cells
Apoptosis
upin cells1
1 study
Apoptosis
upin cells1
PF-04691502 induces apoptosis in cells.
“Additionally, PF-04691502 inhibits the phosphorylation of S6K and AKT, leading to the apoptosis of senescent cells.”
Cellssenescent cells
Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence
Experimental gerontology
Senescent cells
downin cells1
1 study
Senescent cells
downin cells1
PF-04691502 decreases senescent cells in cells.
“PF-04691502, a dual inhibitor of PI3K/AKT and mTOR, specifically eliminates senescent cells.”
Cellssenescent cells
Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence
Experimental gerontology