Peptide yy

Peptide yy has been studied in 5 papers since 2017: none in people yet, 4 in animals, 1 review; 2 in the past year. The research so far is in animals. The newest story, Oct 26, 2026: “Higher gut hormone levels linked to cardiovascular events”.

Intervention

5 papers study it37 more mention it2 findingsUpdated Feb 10, 2026

PubChem MeSH

2 new papers in 30 daysSee all 42 papers on peptide yy

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

2 of 2 findings with company ties

Animals4

What did studies of peptide yy find?

Studies of peptide yy measured 2 outcomes; the most studied are aged-like meal patterns (1 study) and food intake (1).

Aged-like meal patterns

upin mice1

1 study

Peptide yy induces aged-like meal patterns in mice.
“PYY administration to young mice induced aged-like meal patterns”
Animalsmales
Peptide YY induces characteristic meal patterns of aged mice
Hormones and behaviorNov 1, 2017

Food intake

downin mice1

1 study

Peptide yy decreases food intake in mice (greater reduction in aged than young mice).
“the temporal reduction in food intake by exogenous PYY was more prominent in aged mice than in young mice.”
Animalsgreater reduction in aged than young micemales
Peptide YY induces characteristic meal patterns of aged mice
Hormones and behaviorNov 1, 2017

Latest

14 papers in 12 months

Molecular MetabolismFeb 13

GIPR signaling modulates PYY-induced hypophagia and malaise in rodents

Experiments in ratsInterventions

Paper

EBioMedicineFeb 12

Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice

Experiments in micePhysical activity

Paper

Current Opinion in Endocrinology, Diabetes, and ObesityMar 21

Gut hormones and appetite regulation

ReviewInterventions

Paper

NutrientsJan 12

Roux-en-Y Gastric Bypass and Caloric Restriction but Not Gut Hormone-Based Treatments Profoundly Impact the Hypothalamic Transcriptome in Obese Rats

Experiments in ratsDietary restriction

Paper

Hormones and BehaviorNov 1

Peptide YY induces characteristic meal patterns of aged mice

Experiments in 32 miceMechanisms

Paper

ESC Congress 2026 AbstractOct 26

Higher gut hormone levels linked to cardiovascular events

The highest versus lowest third of hormone levels had a cardiovascular event hazard ratio of 1.79 after accounting for age and sex.The highest versus lowest third of hormone levels had a cardiovascular event hazard ratio of 1.79 after accounting for age and sex.

Cohort · 43,318 peopleCardiovascular disease