L-cell density

There is 1 paper on L-cell density in aging research: none in people yet, 1 in animals.

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Physical activity

upin mice1

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Physical activity increases L-cell density in mice (C57BL/6NRJ mice fed ad-libitum chow diet).
“Physical activity induced a slight growth of the small intestine, increased L-cell density, and enhanced glucose-stimulated GLP-1 secretion.”
AnimalsC57BL/6NRJ mice fed ad-libitum chow dietintestinemales
Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice
EBioMedicineFeb 10, 2026

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EBioMedicineFeb 12

Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice

Experiments in micePhysical activity