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Panax japonicus saponins

Panax japonicus saponins has been studied in 4 papers since 2019: none in people yet, 4 in animals. The research so far is in animals. The newest paper, Oct 6, 2023: “Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway”.

Intervention

4 papers study it16 findingsUpdated

See all 4 papers on panax japonicus saponins

At a glance

The findings reach mice, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals4

What did studies of panax japonicus saponins find?

16

Studies of panax japonicus saponins measured 16 outcomes, among them collagen deposition, mTOR signaling and autophagy.

Collagen deposition

downin rats1

1 study

  1. Panax japonicus saponins decrease collagen deposition in aging rats.

    “decreased collagen deposition and cardiomyocyte apoptosis in aging rats”

    Animalsin aging ratsheart

    Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

    Experimental gerontology

More on Collagen deposition

mTOR signaling

downin rats1

1 study

  1. Panax japonicus saponins inhibit mTOR signaling in rats (phosphorylation of mTOR and ULK1(Ser757)).

    “while inhibited the phosphorylation of mTOR and ULK1(Ser757)”

    Animalsphosphorylation of mTOR and ULK1(Ser757)heart

    Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

    Experimental gerontology

More on mTOR signaling

Autophagy

upin rats1

1 study

  1. Panax japonicus saponins activate autophagy in rats (basal autophagy, via AMPK activation).

    “SPJ activated autophagy through the activation of AMPK, which in turn increased the phosphorylation of ULK1(Ser555)”

    Animalsbasal autophagy, via AMPK activationheart

    Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

    Experimental gerontology

More on Autophagy

Apoptosis

downin rats1

1 study

  1. Panax japonicus saponins decrease apoptosis in aging rats.

    “decreased collagen deposition and cardiomyocyte apoptosis in aging rats”

    Animalsin aging ratsheart

    Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

    Experimental gerontology

More on Apoptosis

Cardiac function

upin rats1

1 study

  1. Panax japonicus saponins improve cardiac function in aging rats.

    “SPJ treatment improved the cardiac function, reduced HMI, attenuated myocardial fiber disorder”

    Animalsin aging ratsheart

    Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

    Experimental gerontology

Neuronal degeneration

downin rats1

1 study

  1. Panax japonicus saponins decrease neuronal degeneration in rats (naturally aging).

    “SPJ improved the neuronal degeneration and mitochondrial morphology that are associated with aging.”

    Animalsnaturally aginghippocampus4 monthsn = 8

    Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

    Pharmaceutical biology

Serum cystatin C

downin rats1

1 study

  1. Panax japonicus saponins decrease serum cystatin C in rats (SPJ-H (high-dose) group compared with 24-month group).

    “Compared with those in the 24-month group, the levels of serum UA, Cys C and β2-MG in the SPJ-H group were significantly decreased.”

    AnimalsSPJ-H (high-dose) group compared with 24-month grouptotal saponins

    Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

    Journal of ginseng research

More on Serum cystatin C

NRF2–KEAP1 antioxidant response

upin rats1

1 study

  1. Panax japonicus saponins activate NRF2–KEAP1 antioxidant response in rats (aging rats).

    “the expression of nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) signaling was aggrandized”

    Animalsaging ratstotal saponinskidney

    Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

    Journal of ginseng research

More on NRF2–KEAP1 antioxidant response

NF-κB signaling

downin rats1

1 study

  1. Panax japonicus saponins inhibit NF-κB signaling in rats (aging rats).

    “the expression level of phosphorylated nuclear factor kappa-B (NF-κB) was down-regulated with reduced inflammatory factors”

    Animalsaging ratstotal saponinskidney

    Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

    Journal of ginseng research

More on NF-κB signaling

TGF-β1/Smad signaling

downin rats1

1 study

  1. Panax japonicus saponins inhibit TGF-β1/Smad signaling in rats (aging rats).

    “the levels of TIMP-1, TIMP-2 and transforming growth factor-β1 (TGF-β1)/Smad signaling were decreased”

    Animalsaging ratstotal saponinskidney

    Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

    Journal of ginseng research

All 16

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