CMRO2

1. Overweight decreases CMRO2 in humans (β = -1.12 μmol/100 g/min, 95%CI = (-1.96, -0.28)).

   “Adiposity was associated with lower CMRO2: with overweight (β = -1.12 μmol/100 g/min, 95%CI = (-1.96, -0.28))”

   Humansbrainn = 303

   Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults

   GeroScience·12 Jan 2026

More on Overweight

1. CMRO2 mediates medial temporal atrophy in humans (indirect β = 0.06, 95%CI = (0.01, 0.14)).

   “Among participants aged 70 years, CMRO2 mediated the association between BMI and MTA (indirect β = 0.06, 95%CI = (0.01, 0.14)).”

   Humansmediating BMI to MTA associationbrain

   Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults

   GeroScience·12 Jan 2026

More on Medial temporal atrophy

1. Body roundness index decreases CMRO2 in humans (β = -1.31, 95%CI = (-2.36, -0.27)).

   “higher BRI (β = -1.31, 95%CI = (-2.36, -0.27)) showing stronger effects with advancing age.”

   Humansbrainn = 303

   Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults

   GeroScience·12 Jan 2026

More on Body roundness index

1. Moderate increasing body shape trajectory is associated with CMRO2 in humans (β = -11.40; 95%CI = (-20.90, -1.90)).

   “CMRO2 was lower in moderate increasing (β = -11.40; 95%CI = (-20.90, -1.90)) and high-rising (β = - 12.23; 95%CI = (-23.56, -0.90)) groups.”

   Humansbrainn = 303

   Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults

   GeroScience·12 Jan 2026