2 papers7 findings
Survival
downin rats1
Oskm gene therapy decreases survival in rats.
“in MASH without cirrhosis, exacerbated liver injury and fibrosis, induced tumors, and reduced survival.”
AnimalsMASH without cirrhosis; male Wistar ratsdoxycycline-inducible AAVsingle AAV dosemales
Three-protein combination eased chronic liver disease in rats
Communications biology5 Oct 2026
Liver tumors
upin rats1
Oskm gene therapy induces liver tumors in rats.
“in MASH without cirrhosis, exacerbated liver injury and fibrosis, induced tumors, and reduced survival.”
AnimalsMASH without cirrhosis; male Wistar ratsdoxycycline-inducible AAVliversingle AAV dosemales
Three-protein combination eased chronic liver disease in rats
Communications biology5 Oct 2026
Liver damage
downin rats1
Oskm gene therapy decreases liver damage in rats.
“In warm hepatic ischemia, both OSKM and OSK reduced liver damage.”
Animalswarm hepatic ischemia; male Wistar ratsdoxycycline-inducible AAVliversingle AAV dosemales
Three-protein combination eased chronic liver disease in rats
Communications biology5 Oct 2026
Pathological alterations
no changein rats1
Oskm gene therapy has no effect on pathological alterations in rats.
“Further, OSKM gene expression did not lead to any pathological alterations within the 39 days.”
Animalsviral vectors39 daysfemales
Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy
GeroScience22 Jul 2024
Age-related DNA methylation
downin rats1
Oskm gene therapy decreases age-related DNA methylation in rats.
“an epigenome-wide association analysis indicated that OSKM expression in the hippocampus of old rats partially reversed the age-related increase in methylation.”
Animalsviral vectorshippocampus39 daysfemales
Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy
GeroScience22 Jul 2024
Epigenetic age
downin rats1
Oskm gene therapy decreases epigenetic age in rats.
“First, epigenetic clocks for rats suggested a marginally significant epigenetic rejuvenation.”
Animalsviral vectorshippocampus39 daysfemales
Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy
GeroScience22 Jul 2024
Cognitive function
upin rats1
Oskm gene therapy improves cognitive function in rats.
“The Barnes maze test, used to assess cognitive performance, demonstrated enhanced cognitive abilities in old rats treated with OSKM compared to old control animals.”
AnimalsCompared with old control rats treated with a placebo adenovectorviral vectorshippocampus39 daysfemales
Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy
GeroScience22 Jul 2024
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.