Oridonin

1. Oridonin extends lifespan in mice (+21.6% average life span).

   “extended the average life span of naturally aged mice by 21.6%.”

   Animalsnaturally aged

   Oridonin Delays Aging Through the AKT Signaling Pathway

   Frontiers in pharmacology·May 18, 2022

2. Oridonin extends lifespan in yeast cells (+48.9%).

   “Notably, oridonin prolonged the lifespan of yeast by 48.9%”

   Cells

   Oridonin Delays Aging Through the AKT Signaling Pathway

   Frontiers in pharmacology·May 18, 2022

1. Oridonin inhibits KDM5C in cells.

   “Mechanistically, oridonin inhibited KDM5C histone demethylase, restored H3K4me3 levels, and activated the SIRT2 anti-aging pathway.”

   Cells

   Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression

   Acta pharmaceutica Sinica. B·Feb 10, 2026

More on KDM5C

1. Oridonin decreases pathological remodeling in mice.

   “In vivo and in vitro administration of oridonin significantly ameliorated cardiac dysfunction and pathological remodeling in the CHIP model.”

   Animalsin TET2-mediated clonal hematopoiesis (Tet2 +/- BMT) model

   Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression

   Acta pharmaceutica Sinica. B·Feb 10, 2026

1. Oridonin decreases cardiac dysfunction in mice.

   “In vivo and in vitro administration of oridonin significantly ameliorated cardiac dysfunction and pathological remodeling in the CHIP model.”

   Animalsin TET2-mediated clonal hematopoiesis (Tet2 +/- BMT) model

   Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression

   Acta pharmaceutica Sinica. B·Feb 10, 2026

1. Oridonin induces apoptosis in cells.

   “target a class of glutathione S-transferases to activate ROS-p38 signaling and induce apoptosis in senescent cells”

   Cellssenescent cells

   Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

   Chemical communications (Cambridge, England)·Nov 12, 2022

More on Apoptosis

1. Oridonin induces cell killing (cytotoxicity) in cells.

   “identified oridonin as a novel senolytic”

   Cellssenescent cells

   Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

   Chemical communications (Cambridge, England)·Nov 12, 2022

More on Cell killing (cytotoxicity)

1. Oridonin improves healthspan in mice.

   “Our mice behavior experiments exhibited that oridonin significantly improved the health status of naturally aged mice.”

   Animalsnaturally aged

   Oridonin Delays Aging Through the AKT Signaling Pathway

   Frontiers in pharmacology·May 18, 2022

1. Oridonin decreases cellular senescence in human cells (reduced to 48.5%).

   “Compared with the elderly control group, the positive cell rate in the oridonin intervention group was reduced to 48.5%.”

   Cellsfibroblasts

   Oridonin Delays Aging Through the AKT Signaling Pathway

   Frontiers in pharmacology·May 18, 2022

More on Cellular senescence