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Orexin-a

Intervention

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Animals1
  • Cells1

Outcomes

2

Cellular senescence

downin human cells1

1 study

  1. Orexin-a decreases cellular senescence in human cells.

    “orexin-A treatment ameliorates IL-1β-induced cellular senescence”

    Cellsin IL-1β-treated TC-28a2 chondrocytes

    The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes

    AgingMay 31, 2024

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Substance P

downin rats1

1 study

  1. Orexin-a inhibits substance P in rats.

    “Dental pain-induced SP and CGRP overexpression was also significantly inhibited by orexin-A injection into the TNC of young animals.”

    Animalscapsaicin-induced dental pulp paintrigeminal nucleus caudalis

    Age-dependent down-regulation of orexin receptors in trigeminal nucleus caudalis correlated with attenuation of orexinergic analgesia in rats

    Experimental gerontologyOct 29, 2023

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