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Orchiectomy

Intervention

3 papers2 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: National Center for Advancing Translational Sciences and 6 more
  • 1 of 2 findings with company ties
  • Animals2

Outcomes

2

Myocardial sympathetic activity

downin mice1

1 study

  1. Orchiectomy decreases myocardial sympathetic activity in mice.

    “MSA and catecholamine levels following myocardial injury were highest in young males (p = 0.008 and p = 0.043 vs. young females, respectively) and were reduced by orchiectomy.”

    Animalsfollowing myocardial injurymyocardiummales

    Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury

    Biology of sex differencesJan 16, 2025

Ubiquitin–proteasome system

upin mice1

1 study

  1. Orchiectomy increases ubiquitin–proteasome system in mice.

    “Testosterone depletion resulted in a general increase in proteasome activity at all ages.”

    Animalsorchiectomy-induced testosterone depletionskeletal muscle28 daysmales

    Maintenance of muscle mass in adult male mice is independent of testosterone

    PloS oneMar 25, 2021

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