Ononin

1. Ononin increases superoxide dismutase and glutathione in mice.

   “a decline in SOD and GSH levels that was partially reversed by ononin.”

   AnimalsAnesthesia/unilateral nephrectomy; partial reversal of postoperative reductionshippocampus30 mg/kg

   Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress

   Brain and behavior·30 Sep 2025

More on Superoxide dismutase and glutathione

1. Ononin decreases neuronal damage in mice.

   “Conversely, ononin pretreatment significantly rescued the pathological process and cognitive impairment.”

   AnimalsPretreatment 15 min before anesthesia/unilateral nephrectomyhippocampus30 mg/kg

   Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress

   Brain and behavior·30 Sep 2025

1. Ononin improves cognitive function in mice.

   “Conversely, ononin pretreatment significantly rescued the pathological process and cognitive impairment.”

   AnimalsPretreatment 15 min before anesthesia/unilateral nephrectomy30 mg/kgPostoperative Day 3

   Ononin, a Natural Isoflavone Glycoside, Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Regulating Neuroinflammation and Oxidative Stress

   Brain and behavior·30 Sep 2025