Olaparib

3 papers3 findings

PubChem 23725625 ChEBI 83766

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Animals2
Cells1

Outcomes

3

Cellular senescence

upin human cells1

1 study

Olaparib induces cellular senescence in human cells.
“the use of PARPis (olaparib and niraparib) as maintenance therapies inhibited cell proliferation by causing cellular senescence to exert potent anticancer effects”
Cellsin Capan-1 and PANC-1 cells
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy
Apoptosis : an international journal on programmed cell death9 Feb 2026

More on Cellular senescence

Pulmonary endothelial senescence

downin cells1

1 study

Olaparib decreases pulmonary endothelial senescence in cells.
“olaparib as a potential agent that rescues KLK8-induced pulmonary endothelial cell senescence and alleviates VILI in aged mice”
CellsKLK8-induced
Age-Dependent KLK8 Upregulation Contributes to Elevated Susceptibility to Ventilator-Induced Lung Injury in the Elderly Mice
Aging cell27 Nov 2025

Ventilator-induced lung injury

downin mice1

1 study

Olaparib decreases ventilator-induced lung injury in mice.
“olaparib as a potential agent that rescues KLK8-induced pulmonary endothelial cell senescence and alleviates VILI in aged mice”
Animalsin aged mice with VILI
Age-Dependent KLK8 Upregulation Contributes to Elevated Susceptibility to Ventilator-Induced Lung Injury in the Elderly Mice
Aging cell27 Nov 2025

More on Ventilator-induced lung injury

Latest

3 in 12 months

Apoptosis10 Feb

Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy

Experiments in human cellsPancreatic cancer

Research Square3 Dec

Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax

Preprint: experiments in miceInterventions

Aging Cell28 Nov

Age-Dependent KLK8 Upregulation Contributes to Elevated Susceptibility to Ventilator-Induced Lung Injury in the Elderly Mice

Experiments in miceLung