AgingResearch.NewsJoin free

Obeticholic acid

Intervention

3 papers3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fok Ying Tung Education Foundation and 1 more
  • Animals2
  • Cells1

Outcomes

2

Lifespan

upin mice1upin worms1

1 study

  1. Obeticholic acid extends lifespan in worms.

    “obeticholic acid (OCA), a marketed drug for the treatment of cholestasis, may extend the lifespan and healthspan both in C. elegans and chemical-induced early senescent mice.”

    Model organisms

    Targeting farnesoid X receptor as aging intervention therapy

    Acta pharmaceutica Sinica. BJan 19, 2025

  2. Obeticholic acid extends lifespan in mice.

    “obeticholic acid (OCA), a marketed drug for the treatment of cholestasis, may extend the lifespan and healthspan both in C. elegans and chemical-induced early senescent mice.”

    Animalschemical-induced early senescent mice

    Targeting farnesoid X receptor as aging intervention therapy

    Acta pharmaceutica Sinica. BJan 19, 2025

Resistance to toxicants

upin worms1

1 study

  1. Obeticholic acid increases resistance to toxicants in worms.

    “OCA increased the resistance of worms to toxicants”

    Model organisms

    Targeting farnesoid X receptor as aging intervention therapy

    Acta pharmaceutica Sinica. BJan 19, 2025

Latest

Related