NR1H4
Gene1 paper3 findingsHGNC 7967NCBI Gene 9971Taxon 9606
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
4 of 4 trials sponsored by developers of drugs on it
- Animals1
Effects
3Immune cell activation
upin mice1
1 study
Immune cell activation
upin mice1
NR1H4 increases immune cell activation in mice.
“their regenerating livers showed markedly attenuated immune cell activation and reduced infiltration.”
AnimalsShown by FXR knockout during regeneration after 70% partial hepatectomyliver
A liver receptor helps restore immune cells for repair in mice · Cell death discovery · 9 Oct 2026
Kupffer cell proliferation
upin mice1
1 study
Kupffer cell proliferation
upin mice1
NR1H4 increases kupffer cell proliferation in mice.
“Mechanistically, FXR promotes monocyte migration by targeting Ccr2 and enhances Kupffer cell proliferation via the CSF1/PI3K/Akt signaling pathway”
AnimalsShown by FXR knockout in a 70% partial hepatectomy modelliver
A liver receptor helps restore immune cells for repair in mice · Cell death discovery · 9 Oct 2026
Circulating monocyte migration into the regenerating liver
upin mice1
1 study
Circulating monocyte migration into the regenerating liver
upin mice1
NR1H4 increases circulating monocyte migration into the regenerating liver in mice.
“Our data demonstrate that FXR deficiency impairs both the migration of circulating monocytes into the regenerating liver and the proliferation of resident Kupffer cells.”
AnimalsShown by FXR knockout in a 70% partial hepatectomy modelliver
A liver receptor helps restore immune cells for repair in mice · Cell death discovery · 9 Oct 2026
Latest
1A liver receptor helps restore immune cells for repair in mice
Mice lacking the receptor FXR showed poorer immune cell recruitment and delayed liver regrowth after surgical removal of most of the organ.Mice lacking the receptor FXR showed poorer immune cell recruitment and delayed liver regrowth after surgical removal of most of the organ.