NRF1-PRIMED mesenchymal stem cells

1 paper3 findings

1 lab in 1 country

Funder: Houston Methodist Research Institute

Cells1

Outcomes

3

Oxidative phosphorylation

upin cells1

1 study

NRF1-PRIMED mesenchymal stem cells improve oxidative phosphorylation in cells.
“recipient ECs displayed reduced mitochondrial ROS, preserved membrane potential, improved oxidative phosphorylation and ATP production”
Cellsin recipient ECs
Enhanced intercellular transfer of mitochondria from nuclear respiratory factor 1 (NRF1)-primed mesenchymal stem cells: towards creation of superior mitochondrial delivery hubs
bioRxiv (Cold Spring Harbor Laboratory)9 Feb 2026Preprint

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Apoptosis

downin cells1

1 study

NRF1-PRIMED mesenchymal stem cells decrease apoptosis in cells.
“NRF1-primed MSCs further attenuated oxidative stress-induced EC senescence and apoptosis.”
Cellsin stressed recipient endothelial cells
Enhanced intercellular transfer of mitochondria from nuclear respiratory factor 1 (NRF1)-primed mesenchymal stem cells: towards creation of superior mitochondrial delivery hubs
bioRxiv (Cold Spring Harbor Laboratory)9 Feb 2026Preprint

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Cellular senescence

downin cells1

1 study

NRF1-PRIMED mesenchymal stem cells decrease cellular senescence in cells.
“NRF1-primed MSCs further attenuated oxidative stress-induced EC senescence and apoptosis.”
Cellsin stressed recipient endothelial cells
Enhanced intercellular transfer of mitochondria from nuclear respiratory factor 1 (NRF1)-primed mesenchymal stem cells: towards creation of superior mitochondrial delivery hubs
bioRxiv (Cold Spring Harbor Laboratory)9 Feb 2026Preprint

More on Cellular senescence

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1 in 12 months

bioRxiv9 Feb

Enhanced intercellular transfer of mitochondria from nuclear respiratory factor 1 (NRF1)-primed mesenchymal stem cells: towards creation of superior mitochondrial delivery hubs

Preprint: experiments in cellsInterventions