Nox1 inhibition
Nox1 inhibition has been studied in 1 paper since 2017: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Oct 17, 2017: “The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1”.
1 paper studies it2 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: American Heart Association and 5 more
- Animals1
What did studies of Nox1 inhibition find?
1Studies of Nox1 inhibition measured 1 outcome; the most studied are TSP1-mediated senescence (1 study).
TSP1-mediated senescence
downin human cells1
1 study
TSP1-mediated senescence
downin human cells1
Nox1 inhibition protects against TSP1-mediated senescence in human cells.
“Finally, genetic ablation or pharmacological blockade of Nox1 in human endothelial cells attenuated TSP1-mediated ROS generation, restored cell cycle progression, and protected against senescence.”
CellsTSP1 treatmentendothelial cell
Science signaling
Nox1 inhibition prevents TSP1-mediated senescence in human cells.
“Nox1 inhibition blocked the ability of TSP1 to increase p53 nuclear localization and p21cip abundance and its ability to promote senescence.”
CellsTSP1 treatmentendothelial cell
Science signaling
Latest
Science Signaling
The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
Experiments in miceCellular senescence