AgingResearch.NewsJoin free

TSP1DELETION

Gene

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Heart Association and 5 more
  • Animals1

Effects

1

aging-induced senescence

downin mice1

1 study

  1. TSP1DELETION decreases aging-induced senescence in mice.

    “Mice lacking TSP1 showed decreases in ROS production, p21cip expression, p53 activity, and aging-induced senescence.”

    AnimalsTSP1 knockout

    The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

    Science signaling

Latest

Related