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NMN-loaded hucmsc-sevs

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Government of Jiangsu Province and 2 more
  • Animals1

Outcomes

3

Mitophagy

upin cells1

1 study

  1. NMN-loaded hucmsc-sevs activate mitophagy in cells.

    “NMN-sEVs treatment increased intracellular NAD+ levels and SIRT3 expression, as well as rescued the inhibition of senescence-induced mitochondrial autophagy”

    Cells

    Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD⁺/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging

    Stem cell research & therapy1 Jul 2025

More on Mitophagy

Cellular senescence

downin cells1

1 study

  1. NMN-loaded hucmsc-sevs decrease cellular senescence in cells.

    “delay cellular senescence, and restore cellular mitochondrial dysfunction”

    Cells

    Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD⁺/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging

    Stem cell research & therapy1 Jul 2025

More on Cellular senescence

Skin aging

upin mice1

1 study

  1. NMN-loaded hucmsc-sevs improve skin aging in mice.

    “Our data suggested that NMN-sEVs could improve skin aging in mice”

    Animalsin D-galactose-induced skin aging model

    Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD⁺/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging

    Stem cell research & therapy1 Jul 2025

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