Colorectal cancer
no changein humans1
Nitrite has no effect on colorectal cancer in humans.
“nitrite intake was associated with a dose-dependent higher risk of CRC in men (HR 1.23; 95%CI 1.06-1.43; p-trend<0.05) but not in women.”
Humansfemales
Nitrate and nitrite intake and risk of colorectal cancer: a population-based cohort study
Journal of the National Cancer Institute5 Aug 2026
Distal colon cancer
upin humans1HR 1.5
Nitrite raises the risk of distal colon cancer in humans (HR 1.50, 95% CI 1.13–1.98).
“CRC subsite analyses in men indicated the strongest association for distal colon cancer (HR 1.50; 95% CI: 1.13-1.98).”
Humansdistal colonmales
Nitrate and nitrite intake and risk of colorectal cancer: a population-based cohort study
Journal of the National Cancer Institute5 Aug 2026
Colorectal cancer
upin humans1HR 1.23
Nitrite raises the risk of colorectal cancer in humans (HR 1.23, 95% CI 1.06–1.43).
“nitrite intake was associated with a dose-dependent higher risk of CRC in men (HR 1.23; 95%CI 1.06-1.43; p-trend<0.05)”
Humansmales
Nitrate and nitrite intake and risk of colorectal cancer: a population-based cohort study
Journal of the National Cancer Institute5 Aug 2026
National Institute of Diabetes and Digestive and Kidney DiseasesUS$2.8m
An observational study of 472 people linked nitrate processing by tongue microbes to a lower prevalence of prediabetes.An observational study of 472 people linked nitrate processing by tongue microbes to a lower prevalence of prediabetes.
Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome…Across 60 healthy younger and older adults in the UK and Belgium, researchers found shared bacterial associations with cognitive performance despite geographic microbiome differences.