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Japanese traditional diet

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Japan Society for the Promotion of Science and 1 more
  • Human trial1

Outcomes

4

Nitrite

upin humans1

1 study

  1. Japanese traditional diet increases nitrite in humans.

    “Plasma and salivary levels of nitrate and nitrite were higher at the end of the JTD period.”

    Human trial10-dayn = 25

    Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

    Nitric oxide : biology and chemistry1 Nov 2009

More on Nitrite

Nitrate

upin humans1

1 study

  1. Japanese traditional diet increases nitrate in humans.

    “Plasma and salivary levels of nitrate and nitrite were higher at the end of the JTD period.”

    Human trial10-dayn = 25

    Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

    Nitric oxide : biology and chemistry1 Nov 2009

More on Nitrate

Systolic blood pressure

no changein humans1

1 study

  1. Japanese traditional diet has no effect on systolic blood pressure in humans.

    “systolic BP was not affected”

    Human trial10-dayn = 25

    Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

    Nitric oxide : biology and chemistry1 Nov 2009

Diastolic blood pressure

downin humans1

1 study

  1. Japanese traditional diet decreases diastolic blood pressure in humans (-4.5 mmHg, P=0.0066).

    “Diastolic BP decreased on average 4.5 mmHg during JTD compared to the control diet (P=0.0066)”

    Human trial10-dayn = 25

    Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers

    Nitric oxide : biology and chemistry1 Nov 2009

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