NECROSTATIN-1

1. NECROSTATIN-1 inhibits extracellular matrix remodelling in rat cells.

   “Additionally, NEC1 inhibited the expression of extracellular matrix (ECM) degradation markers (MMP3, MMP9, MMP13) and programmed necrosis indicators (p-MLKL) in chondrocytes.”

   CellsIL-1β+TNF-α treatment

   Necrostatin-1 alleviates temporomandibular joint osteoarthritis and inhibits chondrocyte senescence and necroptosis possibly via p53/ MAPK downregulation

   Frontiers in bioengineering and biotechnology·18 Dec 2025

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1. NECROSTATIN-1 inhibits cellular senescence in rat cells.

   “In vitro, NEC1 (40 μM) exhibited cytoprotective effects on Rat primary condylar chondrocytes (rPCCs), preserving cell viability and reducing cellular senescence markers (Cdkn1a and Cdkn2a) following IL-1β+TNF-α treatment.”

   CellsIL-1β+TNF-α treatment40 μM

   Necrostatin-1 alleviates temporomandibular joint osteoarthritis and inhibits chondrocyte senescence and necroptosis possibly via p53/ MAPK downregulation

   Frontiers in bioengineering and biotechnology·18 Dec 2025

More on Cellular senescence

1. NECROSTATIN-1 protects against temporomandibular joint osteoarthritis in rats.

   “Treatment with NEC1 significantly alleviated the progression of TMJ-OA in rats, reduced pain, and restored cartilage integrity.”

   Animalsmonosodium iodoacetate-induced TMJ-OA

   Necrostatin-1 alleviates temporomandibular joint osteoarthritis and inhibits chondrocyte senescence and necroptosis possibly via p53/ MAPK downregulation

   Frontiers in bioengineering and biotechnology·18 Dec 2025

More on Temporomandibular joint osteoarthritis