N-acetylcysteine amide

Intervention

3 papers4 findings

  • 3 independent labs in 4 countries
  • Funders: Biomedical Advanced Research and Development Authority and 8 more
  • 2 of 4 findings with company ties
  • Animals1
  • Model organisms1
  • Cells1

Outcomes

4

Cellular senescence

downin human cells1

1 study
  1. N-acetylcysteine amide decreases cellular senescence in human cells.

    “NACA exhibited the capacity to mitigate DNA damage and cellular senescence”

    Cellsradiation exposure

    Liver quad culture chip as a model for radiation injury research

    Scientific reports11 Apr 2025

More on Cellular senescence

DNA damage

downin human cells1

1 study
  1. N-acetylcysteine amide decreases DNA damage in human cells.

    “NACA exhibited the capacity to mitigate DNA damage and cellular senescence”

    Cellsradiation exposure

    Liver quad culture chip as a model for radiation injury research

    Scientific reports11 Apr 2025

More on DNA damage

Lens opacity

downin mice1

1 study
  1. N-acetylcysteine amide decreases lens opacity in mice.

    “In ex vivo lens experiments, NACA significantly reduced H2O2-induced lens opacity and preserved lens integrity.”

    Animalsin ex vivo lenses exposed to H2O2

    Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice

    Biomolecules19 Mar 2025

Spreading depolarization event duration

downin locust1

1 study
  1. N-acetylcysteine amide decreases spreading depolarization event duration in locust.

    “pretreatment with the antioxidant, N-acetylcysteine amide, had opposite effects to those of aging, reducing duration, and increasing rate of recovery”

    Model organismsouabain-induced spreading depolarization

    Recovery from spreading depolarization is slowed by aging and accelerated by antioxidant treatment in locusts

    Journal of neurophysiology12 Dec 2024

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