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Multivitamin and mineral supplement

Multivitamin and mineral supplement has been studied in 7 papers since 2000: 6 trials in people, 1 review. The newest paper, Apr 24, 2015: “Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial”.

Intervention

7 papers study it18 findingsUpdated

“In men, the supplement reduced the risk of fracture by 63% during the trial period”
Multivitamin and mineral supplementation is associated with the reduction of fracture risk and hospitalization rate in Chinese adult males: a randomized controlled studyJournal of bone and mineral metabolism2014doi:10.1007/s00774-014-0589-3

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 5 independent labs in 4 countries
  • 2 findings against
  • Funders: Harbin Medical University and 7 more
  • 3 of 17 findings with company ties
  • Human trial6

What did studies of Multivitamin and mineral supplement find?

15

Studies of Multivitamin and mineral supplement measured 15 outcomes; the most studied are body weight (2 studies), depression (1) and cognitive function (1).

Body weight

downin humans1no changein humans1

2 studies

  1. Multivitamin and mineral supplement decreases body weight in humans.

    “After 26 weeks, compared with the placebo group, the MMS group had significantly lower BW, BMI, FM, TC and LDL-C, significantly higher REE and HDL-C”

    Human trialobesetablet26 weeksfemales

    Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women

    International journal of obesity (2005)

  2. Multivitamin and mineral supplement has no effect on body weight in humans.

    “body weight was significantly decreased after the weight-loss intervention (P < 0.001) with no difference between treatment groups.”

    Human trialduring energy restriction15 weeksn = 45

    Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study

    The British journal of nutrition

Depression

no changein humans1

1 study

  1. Multivitamin and mineral supplement has no effect on depression in humans.

    “There were no benefits of the MVMH to mood ratings of depression”

    Human trialacutefemalesn = 76

    Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial

    Age (Dordrecht, Netherlands)

More on Depression

Cognitive function

no changein humans1

1 study

  1. Multivitamin and mineral supplement has no effect on cognitive function in humans.

    “performance was not enhanced on the cognitive battery.”

    Human trialacutefemalesn = 76

    Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial

    Age (Dordrecht, Netherlands)

Calmness

upin humans1

1 study

  1. Multivitamin and mineral supplement increases calmness in humans.

    “measures also demonstrating MVMH-related increased ratings of calmness.”

    Human trialacutefemalesn = 76

    Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial

    Age (Dordrecht, Netherlands)

Mental stress

downin humans1

1 study

  1. Multivitamin and mineral supplement decreases mental stress in humans.

    “the most prominent effects appeared to be a reduction in ratings of perceived mental stress.”

    Human trialacutefemalesn = 76

    Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial

    Age (Dordrecht, Netherlands)

Fracture-related hospitalization

downin humans1

1 study

  1. Multivitamin and mineral supplement decreases fracture-related hospitalization in humans.

    “These results demonstrate that a 6-year multivitamin and mineral intervention was associated with significant reduction of fracture risk and fracture-related hospitalization in men, but not in women.”

    Human trial6 yearsmales

    Multivitamin and mineral supplementation is associated with the reduction of fracture risk and hospitalization rate in Chinese adult males: a randomized controlled study

    Journal of bone and mineral metabolism

Fractures

no changein humans1

1 study

  1. Multivitamin and mineral supplement has no effect on fractures in humans.

    “In women, no significant effect of supplementation on fracture incidence was seen in any of the study periods.”

    Human trial6 yearsfemales

    Multivitamin and mineral supplementation is associated with the reduction of fracture risk and hospitalization rate in Chinese adult males: a randomized controlled study

    Journal of bone and mineral metabolism

More on Fractures

Total cholesterol

downin humans1

1 study

  1. Multivitamin and mineral supplement decreases total cholesterol in humans.

    “the MMS group had significantly lower BW, BMI, FM, TC and LDL-C, significantly higher REE and HDL-C”

    Human trialobesetablet26 weeksfemales

    Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women

    International journal of obesity (2005)

More on Total cholesterol

Resting energy expenditure

upin humans1

1 study

  1. Multivitamin and mineral supplement increases resting energy expenditure in humans.

    “significantly higher REE and HDL-C”

    Human trialobesetablet26 weeksfemales

    Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women

    International journal of obesity (2005)

C-reactive protein

downin humans1

1 study

  1. Multivitamin and mineral supplement decreases C-reactive protein in humans (p < 0.05).

    “the MMS group also had significantly lower serum concentrations of CRP compared with that of baseline and the placebo group (p < 0.05).”

    Human trialobese Chinese women with increased cardiovascular disease risktabletserum26-weekfemalesn = 128

    Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk

    Asia Pacific journal of clinical nutrition

More on C-reactive protein

All 15

What is Multivitamin and mineral supplement linked with?

2

Studies link Multivitamin and mineral supplement with 2 measures, most often cancer (1 study) and fractures (1).

Cancer

downin humans1HR 0.92

1 study

  1. Multivitamin and mineral supplement lowers the risk of cancer in humans (HR 0.92, 95% CI 0.86-0.998).

    “Men taking MVMs experienced a statistically significant 8% reduction in incidence of total cancer (hazard ratio [HR]: 0.92; 95% confidence interval [CI]: 0.86-0.998; p = 0.04).”

    Reviewgenerally healthymultivitamin and mineral supplementmean duration of 11 yearsmales

    Multivitamin/multimineral supplements for cancer prevention: implications for primary care practice

    Postgraduate medicine

More on Cancer

Fractures

downin humans1

1 study

  1. Multivitamin and mineral supplement lowers the risk of fractures in humans (reduced the risk of fracture by 63%).

    “In men, the supplement reduced the risk of fracture by 63% during the trial period”

    Human trial6 yearsmales

    Multivitamin and mineral supplementation is associated with the reduction of fracture risk and hospitalization rate in Chinese adult males: a randomized controlled study

    Journal of bone and mineral metabolism

More on Fractures

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