Mitochondria-targeted esculetin

Intervention1 paper4 findings

Animals1

Outcomes

4

p38 MAPK signalling

downin mouse cells1Very low certainty

1 study

Mitochondria-targeted esculetin inhibits p38 MAPK signalling in mouse cells.
Cellsin H9c2 cardiomyocytes and primary adult mouse cardiac fibroblasts
Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling · Biochemical and biophysical research communications · 10 Sep 2026

p38 MAPK signalling →

AMPK signalling

upin mouse cells1Very low certainty

1 study

Mitochondria-targeted esculetin activates AMPK signalling in mouse cells.
Cellsin H9c2 cardiomyocytes and primary adult mouse cardiac fibroblasts
Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling · Biochemical and biophysical research communications · 10 Sep 2026

AMPK signalling →

Fibrosis

downin mice1Very low certainty

1 study

Mitochondria-targeted esculetin decreases fibrosis in mice.
Animalsaged Apoe-/- mice
Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling · Biochemical and biophysical research communications · 10 Sep 2026

Cardiac hypertrophy

downin mice1Very low certainty

1 study

Mitochondria-targeted esculetin decreases cardiac hypertrophy in mice.
Animalsaged Apoe-/- mice
Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling · Biochemical and biophysical research communications · 10 Sep 2026

Latest

1

Biochemical and Biophysical Research CommunicationsAnimals11 Sep

Mitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling