MIF20
- 1 lab in 1 country
- Funders: National Heart, Lung, and Blood Institute and 4 more
- Animals1
Outcomes
4Oxidative stress and ROS signalling
downin mice1
1 study
Oxidative stress and ROS signalling
downin mice1
MIF20 decreases oxidative stress and ROS signalling in mice.
“MIF20 augments protective metabolic responses by reducing the NADH/NAD ratio, leading to a decrease in the accumulation of reactive oxygen species (ROS) in the aged myocardium under I/R stress.”
Animalsunder I/R stressmyocardium
Metabolism: clinical and experimental15 Jan 2024
Contractile properties
upin mouse cells1
1 study
Contractile properties
upin mouse cells1
MIF20 improves contractile properties in mouse cells.
“We further found MIF20 to contribute to the maintenance of mitochondrial fitness and to preserve the contractile properties of aged cardiomyocytes under hypoxia/reoxygenation.”
Cellsunder hypoxia/reoxygenationcardiomyocytes
Metabolism: clinical and experimental15 Jan 2024
Systolic function
upin mice1
1 study
Systolic function
upin mice1
MIF20 improves systolic function in mice.
“The administration of MIF20 at the onset of reperfusion was found to not only decrease myocardial infarct size but also preserves systolic function in the aged heart.”
Animalsat the onset of reperfusion under I/R stressmyocardium
Metabolism: clinical and experimental15 Jan 2024
Myocardial infarct size
downin mice1
1 study
Myocardial infarct size
downin mice1
MIF20 decreases myocardial infarct size in mice.
“The administration of MIF20 at the onset of reperfusion was found to not only decrease myocardial infarct size but also preserves systolic function in the aged heart.”
Animalsat the onset of reperfusion under I/R stressmyocardium
Metabolism: clinical and experimental15 Jan 2024