Midbrain-type astrocytes

1. Midbrain-type astrocytes inhibit cellular senescence in human cells.

   “release signaling molecules that inhibited neuronal deterioration and senescence while steering microglial cells away from a pro-inflammatory state.”

   Cellsin human cells in vitro

   Preparation of human astrocytes with potent therapeutic functions from human pluripotent stem cells using ventral midbrain patterning

   Journal of advanced research·22 Mar 2024

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1. Midbrain-type astrocytes decrease inflammation in mice.

   “midbrain-type astrocytes demonstrated remarkable effectiveness in alleviating neurodegeneration, neuroinflammation, and the pathologies associated with the accumulation of α-synuclein and Amyloid β proteins.”

   Animalsin Parkinson's disease and Alzheimer's disease mouse models

   Preparation of human astrocytes with potent therapeutic functions from human pluripotent stem cells using ventral midbrain patterning

   Journal of advanced research·22 Mar 2024

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