Mevalonic acid
- 4 independent labs in 3 countries
- Funders: National Natural Science Foundation of China and 2 more
- Animals1
- Model organisms1
Outcomes
4Oocyte quality
upin mice1
1 study
Oocyte quality
upin mice1
Mevalonic acid improves oocyte quality in mice.
“MVA supplementation improved FPP levels, cortical F-actin and the quality of aged oocytes.”
Animalsoocytefemales
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases
Nature aging26 Aug 2025
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Mevalonic acid extends lifespan in worms.
“experiment in Caenorhabditis elegans showed that administrating mevalonate significantly increased the lifespan”
Model organisms
Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling
Life medicine20 Jan 2025
MYC
upin human cells1
1 study
MYC
upin human cells1
Mevalonic acid increases MYC in human cells.
“c-Myc expression and the progression of cell division cycle were restored upon the addition of mevalonate”
Cellsin statin-treated cancer cell lines
Statins decrease the expression of c-Myc protein in cancer cell lines
Molecular and cellular biochemistry17 Oct 2020
Dolichol
upin rats1
1 study
Dolichol
upin rats1
Mevalonic acid increases dolichol in rats.
“during ageing the hepatic Dol accumulation is associated with an increase of HMGCoA reductase activity, which is affected by diet restriction, and with an increase of MVA incorporation in Dol and Chol”
Animalsliver
Age-related changes of cholesterol and dolichol biosynthesis in rat liver
Mechanisms of ageing and development30 Apr 2002