Female subfertility

2 papers1 finding

Animals2

Upstream

1

PDS5B

downin mice1

1 study

PDS5B protects against female subfertility in mice.
“Knockdown or heterozygous knockout of PDS5B caused spindle assembly defects, meiotic arrest, and aneuploidy in oocytes, ultimately leading to female subfertility.”
Animalsknockdown or heterozygous knockout
Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging
Proceedings of the National Academy of Sciences of the United States of America30 Jul 2026

Trial sponsors

Beni-Suef University
1 trialPhase 4148 people

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PNAS30 Jul

Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging

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