Metformin + rivastigmine
Metformin + rivastigmine has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest paper, Jun 25, 2026: “Effect of metformin on anti-Alzheimer activity of rivastigmine in aluminum chloride-induced Alzheimer's disease in rats: A behavioral, biochemical, immunohistopathological evidence of crosstalk between amyloid,…”.
1 paper studies it4 findingsUpdated
See all 1 papers on metformin + rivastigmine
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Assiut University Faculty of Medicine and 1 more
- Animals1
What did studies of metformin + rivastigmine find?
4Studies of metformin + rivastigmine measured 4 outcomes, among them behavioral performance, Caspase-3 immunoreactivity and SQSTM1/p62.
Behavioral performance
no changein rats1
1 study
Behavioral performance
no changein rats1
Metformin + rivastigmine showed no clear effect on behavioral performance in rats (compared with rivastigmine monotherapy).
“The combination of MET + RIVA failed to yield significant differences in behavioral performance [PA, RAM, MWM, and NORT]”
Animalscompared with rivastigmine monotherapymales
European journal of pharmacology
Caspase-3 immunoreactivity
downin rats1
1 study
Caspase-3 immunoreactivity
downin rats1
Metformin + rivastigmine decreases Caspase-3 immunoreactivity in aluminum chloride-induced Alzheimer's disease rats.
“the combination markedly reduced caspase-3 immunoreactivity compared with the diseased group”
Animalsin aluminum chloride-induced Alzheimer's disease ratshippocampusmales
European journal of pharmacology
SQSTM1/p62
downin rats1
1 study
SQSTM1/p62
downin rats1
Metformin + rivastigmine decreases SQSTM1/p62 in aluminum chloride-induced Alzheimer's disease rats.
“the combination therapy showed significant reductions in hippocampal BACE1, Aβ deposition, and SQSTM1/p62 levels”
Animalsin aluminum chloride-induced Alzheimer's disease ratshippocampusmales
European journal of pharmacology
Amyloid-beta deposition
downin rats1
1 study
Amyloid-beta deposition
downin rats1
Metformin + rivastigmine decreases amyloid-beta deposition in aluminum chloride-induced Alzheimer's disease rats.
“the combination therapy showed significant reductions in hippocampal BACE1, Aβ deposition, and SQSTM1/p62 levels”
Animalsin aluminum chloride-induced Alzheimer's disease ratshippocampusmales
European journal of pharmacology