Mechanical stimulation

1. Mechanical stimulation induces DNA damage response.

   “excessive force induces chromatin overextension and DNA damage, indicating the necessity of precise force control.”

   Animalsexcessive force

   Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling

   Nature communications·13 Jan 2026

More on DNA damage response

1. Mechanical stimulation increases FOXO1 in mice.

   “Moderate mechanical stimulation in cell culture and in mice restores cellular force, increases chromatin accessibility at the FOXO1 locus, activates its expression, and reverses cellular senescence and bone aging.”

   Animalsmoderate

   Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling

   Nature communications·13 Jan 2026

More on FOXO1

1. Mechanical stimulation decreases cellular senescence in mice.

   “Moderate mechanical stimulation in cell culture and in mice restores cellular force, increases chromatin accessibility at the FOXO1 locus, activates its expression, and reverses cellular senescence and bone aging.”

   Animalsmoderate

   Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling

   Nature communications·13 Jan 2026

More on Cellular senescence

1. Mechanical stimulation improves physical function in mice.

   “These mechanical interventions also improve physical performance in aged female mice”

   Animalsmoderatefemales

   Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling

   Nature communications·13 Jan 2026