Malate
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Latest
5 papers in 12 monthsFrontiers in Aging Neuroscience
Changes in the brain [NAD⁺]/[NADH] and [NADPH]/[NADP⁺] with aging and anti-aging dietary restriction
Computational studyMechanisms
American Journal of Physiology Regulatory, Integrative and Comparative Physiology
Peripheral blood mononuclear cell mitochondrial bioenergetics are related to vascular endothelial function in young and older adults
Cohort study in peopleOxidative phosphorylation
Journal of Medicinal Chemistry
Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities
Experiments in wormsInterventions
Free Radical Biology & Medicine
Age-dependent reprogramming of vascular metabolism compromises endothelial resilience to inflammation-induced endothelial dysfunction
Experiments in animalsOxidative phosphorylation
AAIC 2025 Abstract
Detecting Metabolic Changes in Aging Progression and Alzheimer's Disease Using Non‐Invasive Imaging
Experiments in miceAlzheimer's disease
Free Radical Biology & Medicine
Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner
Experiments in miceInterventions
Signal Transduction and Targeted Therapy
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification
Experiments in miceInterventions
Biochimica et Biophysica Acta Molecular Basis of Disease
Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models
Experiments in animalsFatty acid β-oxidation
Journal of Biochemical and Molecular Toxicology
Malate dehydrogenase-2 inhibition shields renal tubular epithelial cells from anoxia-reoxygenation injury by reducing reactive oxygen species
Experiments in human cellsOxidative stress and ROS signaling